Journal: ImmunoHorizons
Article Title: Aspergillus fumigatus –Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma
doi: 10.4049/immunohorizons.1900046
Figure Lengend Snippet: ( A ) R in Alp1-challenged F2rl1 −/ − mice that lack PAR2 expression (two to seven mice per group). ( B and C ) Total cell counts (B) and cell composition (C) in BALF. (B) * p = 0.01, unpaired t test. ( D ) Lung inflammation and airway mucin evaluated by H& E (left) and PAS (right) staining. Images are representative of three to five mice per group. Original magnification ×10. ( E ) PAS + area within the airway epithelium. ( F ) IL-4, IL-5, and IL-13 levels in BALF. All symbols in bar graphs represent results from an individual mouse; error bars are mean ± SEM.; all results represent at least two independent experiments.
Article Snippet: BALB/c, C57BL/6, Δdbl-gata , and protease-activated receptor 2 (PAR2)–deficient ( F2rl1 −/− ) mice were obtained from The Jackson Laboratory.
Techniques: Expressing, Staining